BIOENGINEERED FOR TOUGH DFUs
With living fibroblasts to build granulation tissue and a robust bioabsorbable scaffold, Dermagraft is uniquely designed for DFUs, even in weight-bearing patients.1-7
HOW DERMAGRAFT WORKS
Dermagraft helps restore the compromised DFU dermal bed to facilitate healing by building granulation tissue and stimulating the patient's own epithelial cells to migrate and close the wound.7
Dermagraft, with living
human fibroblasts and a
scaffold, is placed on a
compromised wound bed
Patient's own cells
to migrate and
close the wound
PRODUCT AND APPLICATION DETAILS
- Dermagraft is a cryopreserved human fibroblast-derived dermal substitute containing metabolically active human fibroblasts seeded on a bioabsorbable scaffold1
- Human fibroblasts proliferate to produce human collagen, ECM proteins, human growth factors, and cytokines1
- Dermagraft is FDA-approved to heal DFUs
Dermagraft is indicated for use in the treatment of full-thickness DFUs greater than 6 weeks duration that extend through the dermis but without tendon, muscle, joint capsule, or bone exposure. Dermagraft should be used in conjunction with standard wound care regimens and in patients who have adequate blood supply to the involved foot.1
Dermagraft may be applied weekly for up to 8 applications over a 12-week period.1
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Please refer to the Dermagraft Directions for Use for complete prescribing information.
- Dermagraft Directions for Use. Organogenesis Inc; 2015.
- Data on File -016 and -017. Organogenesis Inc.
- Bainbridge P. J Wound Care. 2013;22(8):407-412.
- Falanga V. Lancet. 2005;366:1736-1743.
- Broughton G, et al. Plast Reconstr Surg. 2006;117(Suppl):12S-34S.
- Roberts C, et al. Can J Plast Surg. 2002;10(Suppl A):6A-13A.
- Marston WA, et al. Diabetes Care. 2003;26(6):1701-1705.
- Conn J, et al. Am J Surg. 1974;128:19-23.
- Munton CGF, et al. Br J Ophthal. 1974;58:941-947.
- Deeken CR, Matthews BD. ISRN Surgery. 2013, Article ID 238067, 12 pages.
- Matlaga BF, et al. J Biomed Mat Res. 1983;17:185-197.
- Chattopadhyay S, et al. Biopolymers. 2014;101(8):821-833.
- Parenteau-Bareil R, et al. Materials. 2010;3:1863-1887.
- Tsugawa AJ, Verstraete FJM. Chapter 7 - Suture materials and biomaterials. In: Oral and Maxillofacial Surgery in Dogs and Cats. Elsevier, 2012, p69-78.